Tag: flu
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pH-responsive nanoparticles for targeted drug delivery
This novel technology may reduce side effects and enhance treatment outcomes for a wide range of diseases.
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Expansive discovery of diverse macrocycles
In a new study in Science, we introduce an AI-assisted drug discovery approach and use it to generate over 14.9 million never-before-seen peptides with appealing pharmaceutical features, including molecules that inhibit key proteins linked to coronavirus infection and cancer in the lab. This research was led by Patrick Salveson, a recent postdoc in the lab.…
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Simplifying nanoscale design with regular protein building blocks
Consistent protein parts allow builders to create biomaterials according to their needs.
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Modeling and generating more of life’s building blocks
All-atom versions of the modeling tool RoseTTAFold and the design tool RFdiffusion are now freely accessible to the scientific community.
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Congrats Bingxu!
Postdoctoral scholar Bingxu Liu, PhD, has won two immunology awards. He’s now using protein design to build sensors for a wide range of molecules.
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Designing hydrogels with the DeForest Lab
Initial results from our efforts to design protein hydrogels were published today in PNAS. Recent postdoctoral scholar Rubul Mout led this research together with Ross Bretherton, a recent graduate student in the DeForest Lab. Science writer Sarah McQuate wrote about the project for the UW Newsroom. From UW News When researchers want to study how…
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Designing binders with the highest affinity ever reported
This week we report in Nature an AI-enabled advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Using a combination of traditional and deep learning based molecular design approaches, we’ve created proteins that bind with exceptionally high affinity and specificity to a variety of challenging biomarkers, including human hormones. Notably, we…
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A new path to carbon storage
Today we published new research that may one day be applied to help remove large amounts of excess carbon from the environment. In a paper appearing in Nature Communications, we show that custom proteins can drive the formation of carbon-rich minerals in laboratory settings. This offers a potential pathway for enhanced carbon storage via engineered organisms. This…