Tag: binder
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SCI-STEM Symposium 2020
The Institute for Protein Design at the University of Washington held the second symposium aimed at providing strategies to address diversity challenges in science, technology, engineering, and math (STEM). The Strategies for Cultivating Inclusion in STEM (SCI-STEM) symposium featured leading keynote speakers, panel discussions, and interactive breakout sessions. Members of the STEM community at all…
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Congrats, Dr Nattermann!
Baker lab graduate student Una Nattermann defended today! Her talk titled “A Hierarchical Approach To The Design Of Protein Crystals” was attended by friends and family as well as current and former members of the lab.
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Neville wins HHMI Hanna Gray Fellowship!
Congratulations to postdoc Neville Bethel for his selection as a Hanna H. Gray Fellow! Neville is one of 15 exceptional early career scientists selected by HHMI for support this year. His research is focused on understand through design the mechanical properties of supramolecular assemblies. “HHMI is committed to supporting people who will solve some of the greatest problems in science,”…
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Congrats, Dr Harley Pyles!
Baker lab graduate student Harley Pyles defended today! His talk was titled “Controlling Protein Assembly on a Mineral Surface with Designed Interfaces.” You can read more about his work here.
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Introducing LOCKR: a bioactive protein switch
Today we report in Nature the design and initial applications of the first completely artificial protein switch that can work inside living cells to modify—or even commandeer—the cell’s complex internal circuitry. The switch is dubbed LOCKR, short for Latching, Orthogonal Cage/Key pRotein. “In the same way that integrated circuits enabled the explosion of the computer…
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Coevolution at the proteome scale
Today we report in Science the identification of hundreds of previously uncharacterized protein–protein interactions in E. coli and the pathogenic bacterium M. tuberculosis. These include both previously unknown protein complexes and previously uncharacterized components of known complexes. This research was led by postdoctoral fellow Qian Cong and included former Baker lab graduate student Sergey Ovchinnikov, now a…
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Protein arrays on mineral surfaces
Today we report the design of synthetic protein arrays that assemble on the surface of mica, a common and exceptionally smooth crystalline mineral. This work, which was performed in collaboration with the De Yoreo lab at PNNL, provides a foundation for understanding how protein-crystal interactions can be systematically programmed. Designed proteins (orange) form a honeycomb-like…
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Protein design by citizen scientists
Citizen scientists can now use Foldit to successfully design synthetic proteins. The initial results of this unique collaboration appear today in Nature. Brian Koepnick, a recent PhD graduate in the Baker lab, led a team that worked on Foldit behind the scenes, introducing new features into the game that they believed would help players home in…