Tag: binder
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Congrats, Dr. Chidyausiku!
Baker lab graduate student Tamuka Chidyausiku successfully defended today! His talk was titled “Structural Insights from Beta-Sandwich Proteins Inform the Design of De novo Immunoglobulin Domains.” Congratulations, Dr. Muk!
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Designed ligands tune cytokine signaling
Today we share some exciting collaborative results of our efforts to design rigid and tunable receptor dimerizers! The first authors of this report are Kritika Mohan and George Ueda. From Science: Exploring a range of signaling Cytokines are small proteins that bind to the extracellular domains of transmembrane receptors to activate signaling pathways inside the cell. They often…
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Congrats, Drs. Klima & Shen!
Baker lab graduate students Jason Klima and Hao Shen successfully defended this week! Jason’s doctoral work focused on the design of mini fluorescence-activating proteins as pH and calcium biosensors. Hao’s work focused on the de novo design of self-assembling helical protein filaments. We are so proud of both of these outstanding doctors!
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Tunable pH-dependent assemblies
Natural proteins often shift their shapes in precise ways in order to function. Achieving similar molecular rearrangements by design, however, has been a long-standing challenge. Today, a team of researchers lead by scientists at the IPD report in Science the rational design of synthetic proteins that move in response to their environment in predictable and tunable…
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Receptor sub-type binders
This week we report in NSMB a combined computational design and experimental selection approach for creating proteins that bind selectively to closely related receptor subtypes. This project was led by Luke Dang, a former Baker lab graduate student, and Yi Miao, a postdoctoral researcher in Christopher Garcia’s lab at Stanford. Abstract: To discriminate between closely related members of…
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De novo 2D arrays
This week we report in JACS a general approach for designing self-assembling 2D protein arrays. This project was led by Zibo Chen, a recent Baker lab graduate student, and featured collaborators from the, DiMaio, De Yoreo and Kollman labs at UW. Abstract: Modular self-assembly of biomolecules in two dimensions (2D) is straightforward with DNA but has been…
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Congrats, Dr. Langan!
Bobby Langan became the latest Baker lab graduate today after successfully defending his PhD! Bobby helped pioneer the design of a molecular switch system dubbed LOCKR, and showed that LOCKR can be used to control the behavior of living cells. Keep an eye out for a series of papers detailing this exciting project, due out soon.…
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Mini proteins, big impact: a profile of Gabriel Rockin
After fundamentally changing how we design proteins at the IPD, Gabe will soon start his own lab at Northwestern’s Center for Synthetic Biology in Chicago. In the 1990s, Silicon Valley produced a lot of computer nerds. Gabriel Rocklin admits he was one of them. But perhaps because he fit the computer nerd stereotype so…