Tag: Peilong Lu
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De novo design of protein logic gates
The same basic tools that allow computers to function are now being used to control life at the molecular level, with implications for future medicines and synthetic biology. Together with collaborators, we have created artificial proteins that function as molecular logic gates. These tools, like their electronic counterparts, can be used to program the behavior of…
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Designing shape-shifting proteins
Today we report the design of protein sequences that adopt more than one well-folded structure, reminiscent of viral fusion proteins. This research moves us closer to creating artificial protein systems with reliable moving parts. In nature, many proteins change shape in response to their environment. This plasticity is often linked to biological function. While computational…
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SCI-STEM Symposium 2020
The Institute for Protein Design at the University of Washington held the second symposium aimed at providing strategies to address diversity challenges in science, technology, engineering, and math (STEM). The Strategies for Cultivating Inclusion in STEM (SCI-STEM) symposium featured leading keynote speakers, panel discussions, and interactive breakout sessions. Members of the STEM community at all…
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Congrats, Dr Nattermann!
Baker lab graduate student Una Nattermann defended today! Her talk titled “A Hierarchical Approach To The Design Of Protein Crystals” was attended by friends and family as well as current and former members of the lab.
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Neville wins HHMI Hanna Gray Fellowship!
Congratulations to postdoc Neville Bethel for his selection as a Hanna H. Gray Fellow! Neville is one of 15 exceptional early career scientists selected by HHMI for support this year. His research is focused on understand through design the mechanical properties of supramolecular assemblies. “HHMI is committed to supporting people who will solve some of the greatest problems in science,”…
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Congrats, Dr Harley Pyles!
Baker lab graduate student Harley Pyles defended today! His talk was titled “Controlling Protein Assembly on a Mineral Surface with Designed Interfaces.” You can read more about his work here.
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Introducing LOCKR: a bioactive protein switch
Today we report in Nature the design and initial applications of the first completely artificial protein switch that can work inside living cells to modify—or even commandeer—the cell’s complex internal circuitry. The switch is dubbed LOCKR, short for Latching, Orthogonal Cage/Key pRotein. “In the same way that integrated circuits enabled the explosion of the computer…
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Coevolution at the proteome scale
Today we report in Science the identification of hundreds of previously uncharacterized protein–protein interactions in E. coli and the pathogenic bacterium M. tuberculosis. These include both previously unknown protein complexes and previously uncharacterized components of known complexes. This research was led by postdoctoral fellow Qian Cong and included former Baker lab graduate student Sergey Ovchinnikov, now a…