Tag: protein design
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Computational design of Flu Glue
Today, a multidisciplinary team of researchers at the University of Washington, Fred Hutch, and The Scripps Research Institute published in Nature Biotechnology the computational design of a trimeric influenza-neutralizing protein that binds extremely tightly to the H3 hemagglutinin of 1968 Hong Kong pandemic influenza virus (A/Hong Kong/X31/1968). It also cross-reacts with human relevant H1, H2…
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The lab goes to Paradise
After months of grey Seattle skies, the lab leapt at a chance to synthesize some vitamin D in Paradise (an actual place at the base of Mount Rainier). Some snowshoed, some skied, and others showed up in the afternoon for a delicious lab BBQ. Couldn’t ask for a more beautiful day! [envira-gallery id=”1572″]
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In case you missed it…
Protein design was a Science magazine runner up breakthrough of the year: http://www.sciencemag.org/news/2016/12/ai-protein-folding-our-breakthrough-runners (We got beat out by gravitational waves).
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Protein structure determination using metagenome sequence data
Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families and that metagenome sequence data more than triple the number…
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Principles for designing proteins with cavities formed by curved β sheets
Some of the key functions of the proteins in our bodies and in all living things are to catalyze chemical reactions—speed up the rates by many orders of magnitude-and to sense and respond to small molecules in the body and in the environment. New proteins that catalyze chemical reactions and/or sense and respond to compounds…
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Baker Lab website soon to be searchable on Google!
For some reason, this website was not populating when any combination of “Baker” and “lab” was searched through Google. We hope to have remedied this, and I am using this post as a way to get Google to crawl faster (by adding new “content”). Thanks to everyone who has been notifying me of this issue.…
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Halloween 2016 – Rise of the Davids
Happy Halloween! We celebrated early because a party on Monday isn’t as good as a Friday, of course. Take a look at the great costumes this year – it’ll have you seeing double, no, a score! There was also a menagerie of animals running amok, a beaten-up pinata, and an absolutely TERRIFYING scarecrow. [envira-gallery id=”1481″]
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Accurate de novo design of hyperstable constrained peptides
Small constrained peptides combine the stability of small molecule drugs with the selectivity and potency of antibody-based therapeutics. However, peptide-based therapeutics have largely remained underexplored due to the limited diversity of naturally occurring peptide scaffolds, and a lack of methods to design them rationally. In an article published in Nature this week, Baker lab scientists…