Preprints

Publications

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1.

Huang, Buwei; Abedi, Mohamad; Ahn, Green; Coventry, Brian; Sappington, Isaac; Tang, Cong; Wang, Rong; Schlichthaerle, Thomas; Zhang, Jason Z.; Wang, Yujia; Goreshnik, Inna; Chiu, Ching Wen; Chazin-Gray, Adam; Chan, Sidney; Gerben, Stacey; Murray, Analisa; Wang, Shunzhi; O’Neill, Jason; Yi, Li; Yeh, Ronald; Misquith, Ayesha; Wolf, Anitra; Tomasovic, Luke M.; Piraner, Dan I.; Gonzalez, Maria J. Duran; Bennett, Nathaniel R.; Venkatesh, Preetham; Ahlrichs, Maggie; Dobbins, Craig; Yang, Wei; Wang, Xinru; Sahtoe, Danny D.; Vafeados, Dionne; Mout, Rubul; Shivaei, Shirin; Cao, Longxing; Carter, Lauren; Stewart, Lance; Spangler, Jamie B.; Roybal, Kole T.; Greisen, Per Jr; Li, Xiaochun; Bernardes, Gonçalo J. L.; Bertozzi, Carolyn R.; Baker, David

Designed endocytosis-inducing proteins degrade targets and amplify signals Journal Article

In: Nature, 2024.

Abstract | Links | BibTeX

2.

Berhanu, Samuel; Majumder, Sagardip; Müntener, Thomas; Whitehouse, James; Berner, Carolin; Bera, Asim K.; Kang, Alex; Liang, Binyong; Khan, Nasir; Sankaran, Banumathi; Tamm, Lukas K.; Brockwell, David J.; Hiller, Sebastian; Radford, Sheena E.; Baker, David; Vorobieva, Anastassia A.

Sculpting conducting nanopore size and shape through de novo protein design Journal Article

In: Science, 2024.

Abstract | Links | BibTeX

3.

Peruzzi, Justin A.; Gunnels, Taylor F.; Edelstein, Hailey I.; Lu, Peilong; Baker, David; Leonard, Joshua N.; Kamat, Neha P.

Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions Journal Article

In: Nature Communications, 2024.

Abstract | Links | BibTeX

4.

Hicks DR An L, Zorine D

Hallucination of closed repeat proteins containing central pockets Journal Article

In: Nature Structural & Molecular Biology, 2023.

Abstract | Links | BibTeX

5.

Wang, Jing Yang (John); Khmelinskaia, Alena; Sheffler, William; Miranda, Marcos C.; Antanasijevic, Aleksandar; Borst, Andrew J.; Torres, Susana V.; Shu, Chelsea; Hsia, Yang; Nattermann, Una; Ellis, Daniel; Walkey, Carl; Ahlrichs, Maggie; Chan, Sidney; Kang, Alex; Nguyen, Hannah; Sydeman, Claire; Sankaran, Banumathi; Wu, Mengyu; Bera, Asim K.; Carter, Lauren; Fiala, Brooke; Murphy, Michael; Baker, David; Ward, Andrew B.; King, Neil P.

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains Journal Article

In: Proceedings of the National Academy of Sciences, 2023.

Abstract | Links | BibTeX

6.

Vorobieva, Anastassia A.; White, Paul; Liang, Binyong; Horne, Jim E.; Bera, Asim K.; Chow, Cameron M.; Gerben, Stacey; Marx, Sinduja; Kang, Alex; Stiving, Alyssa Q.; Harvey, Sophie R.; Marx, Dagan C.; Khan, G. Nasir; Fleming, Karen G.; Wysocki, Vicki H.; Brockwell, David J.; Tamm, Lukas K.; Radford, Sheena E.; Baker, David

De novo design of transmembrane beta barrels Journal Article

In: Science, vol. 371, no. 6531, 2021.

Abstract | Links | BibTeX

7.

Xu, Chunfu; Lu, Peilong; El-Din, Tamer M. Gamal; Pei, Xue Y.; Johnson, Matthew C.; Uyeda, Atsuko; Bick, Matthew J.; Xu, Qi; Jiang, Daohua; Bai, Hua; Reggiano, Gabriella; Hsia, Yang; Brunette, T J; Dou, Jiayi; Ma, Dan; Lynch, Eric M.; Boyken, Scott E.; Huang, Po-Ssu; Stewart, Lance; DiMaio, Frank; Kollman, Justin M.; Luisi, Ben F.; Matsuura, Tomoaki; Catterall, William A.; Baker, David

Computational design of transmembrane pores Journal Article

In: Nature, vol. 585, pp. 129–134, 2020.

Abstract | Links | BibTeX

8.

Lu, Peilong; Min, Duyoung; DiMaio, Frank; Wei, Kathy Y.; Vahey, Michael D.; Boyken, Scott E.; Chen, Zibo; Fallas, Jorge A.; Ueda, George; Sheffler, William; Mulligan, Vikram Khipple; Xu, Wenqing; Bowie, James U.; Baker, David

Accurate computational design of multipass transmembrane proteins Journal Article

In: Science, vol. 359, no. 6379, pp. 1042–1046, 2018, ISSN: 0036-8075.

Abstract | Links | BibTeX

9.

Bergeron, Julien R C; Worrall, Liam J; De, Soumya; Sgourakis, Nikolaos G; Cheung, Adrienne H; Lameignere, Emilie; Okon, Mark; Wasney, Gregory A; Baker, David; McIntosh, Lawrence P; Strynadka, Natalie C J

The modular structure of the inner-membrane ring component PrgK facilitates assembly of the type III secretion system basal body Journal Article

In: Structure (London, England : 1993), vol. 23, pp. 161-72, 2015, ISSN: 1878-4186.

Abstract | Links | BibTeX

10.

Chen, Kuang-Yui M; Sun, Jiaming; Salvo, Jason S; Baker, David; Barth, Patrick

High-resolution modeling of transmembrane helical protein structures from distant homologues. Journal Article

In: PLoS computational biology, vol. 10, pp. e1003636, 2014, ISSN: 1553-7358.

Abstract | Links | BibTeX

11.

Yarov-Yarovoy, Vladimir; DeCaen, Paul G; Westenbroek, Ruth E; Pan, Chien-Yuan; Scheuer, Todd; Baker, David; Catterall, William A

Structural basis for gating charge movement in the voltage sensor of a sodium channel Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 109, pp. E93-102, 2012, ISSN: 1091-6490.

Abstract | Links | BibTeX

12.

Saha, Piyali; Barua, Bipasha; Bhattacharyya, Sanchari; Balamurali, M M; Schief, William R; Baker, David; Varadarajan, Raghavan

Design and characterization of stabilized derivatives of human CD4D12 and CD4D1 Journal Article

In: Biochemistry, vol. 50, pp. 7891-900, 2011, ISSN: 1520-4995.

Abstract | Links | BibTeX

13.

Sanowar, Sarah; Singh, Pragya; Pfuetzner, Richard A; Andr’e, Ingemar; Zheng, Hongjin; Spreter, Thomas; Strynadka, Natalie C J; Gonen, Tamir; Baker, David; Goodlett, David R; Miller, Samuel I

Interactions of the Transmembrane Polymeric Rings of the Salmonella enterica Serovar Typhimurium Type III Secretion System Journal Article

In: mBio, vol. 1, 2010, ISSN: 2150-7511.

Abstract | BibTeX

14.

Zhu, Jieqing; Luo, Bing-Hao; Barth, Patrick; Schonbrun, Jack; Baker, David; Springer, Timothy A

The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3 Journal Article

In: Molecular cell, vol. 34, pp. 234-49, 2009, ISSN: 1097-4164.

Abstract | BibTeX

15.

Luo, Bing-Hao; Karanicolas, John; Harmacek, Laura D; Baker, David; Springer, Timothy A

Rationally designed integrin beta3 mutants stabilized in the high affinity conformation Journal Article

In: The Journal of biological chemistry, vol. 284, pp. 3917-24, 2009, ISSN: 0021-9258.

Abstract | BibTeX

16.

Barth, P; Schonbrun, J; Baker, David

Toward high-resolution prediction and design of transmembrane helical protein structures Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 15682-7, 2007, ISSN: 0027-8424.

Abstract | Links | BibTeX

17.

Yarov-Yarovoy, Vladimir; Schonbrun, Jack; Baker, David

Multipass membrane protein structure prediction using Rosetta Journal Article

In: Proteins, vol. 62, pp. 1010-25, 2006, ISSN: 1097-0134.

Abstract | Links | BibTeX