We seek to understand the fundamental principles underlying protein structure and function, to encode these principles in the Rosetta computer program, and to use them to create a new world of de novo designed proteins to address 21st-century challenges in health and technology. In all cases, we start entirely from first principles; we do not re-engineer native proteins. By iterating between computation and experiment, we continually improve our design methodology.
We are always looking for talented, enthusiastic, and diverse scientists to join our efforts. Our philosophy is that the more closely interacting a research group is, the better the science and the more fun overall.