Category: Publications

  • Congratulations Xinru!

    Congratulations Xinru!

    Postdoctoral scholar Xinru Wang, PhD, has just been named a 2024 Leading Edge Fellow!

  • pH-responsive nanoparticles for targeted drug delivery

    pH-responsive nanoparticles for targeted drug delivery

    This novel technology may reduce side effects and enhance treatment outcomes for a wide range of diseases.

  • Expansive discovery of diverse macrocycles

    Expansive discovery of diverse macrocycles

    In a new study in Science, we introduce an AI-assisted drug discovery approach and use it to generate over 14.9 million never-before-seen peptides with appealing pharmaceutical features, including molecules that inhibit key proteins linked to coronavirus infection and cancer in the lab. This research was led by Patrick Salveson, a recent postdoc in the lab.…

  • Simplifying nanoscale design with regular protein building blocks

    Simplifying nanoscale design with regular protein building blocks

    Consistent protein parts allow builders to create biomaterials according to their needs.

  • Modeling and generating more of life’s building blocks

    Modeling and generating more of life’s building blocks

    All-atom versions of the modeling tool RoseTTAFold and the design tool RFdiffusion are now freely accessible to the scientific community.

  • Congratulations Bingxu!

    Congratulations Bingxu!

    Bingxu Liu, PhD, a postdoctoral scholar in the lab, has recieved two awards for his immunology research. The first is the 2024 Michelson Philanthropies & Science Prize for Immunology. This award recognizes research he performed as a graduate student at MIT on the role Stimulator of Interferon Genes, or STING, plays in defending against viruses,…

  • Designing hydrogels with the DeForest Lab

    Designing hydrogels with the DeForest Lab

    Initial results from our efforts to design protein hydrogels were published today in PNAS. Recent postdoctoral scholar Rubul Mout led this research together with Ross Bretherton, a recent graduate student in the DeForest Lab. Science writer Sarah McQuate wrote about the project for the UW Newsroom. From UW News When researchers want to study how…

  • Designing binders with the highest affinity ever reported

    Designing binders with the highest affinity ever reported

    This week we report in Nature an AI-enabled advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Using a combination of traditional and deep learning based molecular design approaches, we’ve created proteins that bind with exceptionally high affinity and specificity to a variety of challenging biomarkers, including human hormones. Notably, we…