This week we report in Nature [PDF] the design of new transmembrane proteins that allow cells to take in certain chemicals, including charged ions and larger fluorescent molecules. This research could enable new forms of drug delivery and allow for better control over the electrical activity of living cells. All cells are studded with tiny protein …
Fentanyl, one of the most widely used synthetic opioids in clinical practice, has become a widespread drug of abuse and has played a central role in the growing opioid epidemic. With a potency 100-times that of morphine, fentanyl can prove lethal in small doses. Using a fully-automated design pipeline, we have generated high-affinity fentanyl sensors …
Today, a multidisciplinary team of researchers at the University of Washington, Fred Hutch, and The Scripps Research Institute published in Nature Biotechnology the computational design of a trimeric influenza-neutralizing protein that binds extremely tightly to the H3 hemagglutinin of 1968 Hong Kong pandemic influenza virus (A/Hong Kong/X31/1968). It also cross-reacts with human relevant H1, H2 …