Fentanyl, one of the most widely used synthetic opioids in clinical practice, has become a widespread drug of abuse and has played a central role in the growing opioid epidemic. With a potency 100-times that of morphine, fentanyl can prove lethal in small doses. Using a fully-automated design pipeline, we have generated high-affinity fentanyl sensors …
Today, a multidisciplinary team of researchers at the University of Washington, Fred Hutch, and The Scripps Research Institute published in Nature Biotechnology the computational design of a trimeric influenza-neutralizing protein that binds extremely tightly to the H3 hemagglutinin of 1968 Hong Kong pandemic influenza virus (A/Hong Kong/X31/1968). It also cross-reacts with human relevant H1, H2 …