Gabriel Rocklin, PhD


About Me:

Claremont McKenna College, B.A. Biology-Chemistry B.A. History

University of California San Francisco, PhD Biophysics


I am a biophysicist interested in the basic principles of protein stability and molecular interactions. In the Baker Lab, I am studying the stability of simple designed proteins in high-throughput, using a new stability assay and next-generation DNA library synthesis. This has enabled a much larger degree of feedback between modeling and experiment, and should provide a new quantitative understanding of the structural requirements for protein stability. My research is supported by a postdoctoral fellowship from the Life Sciences Research Foundation, sponsored by Merck.


7. Rocklin GJ, Mobley DL, Dill KA, Hünenberger PE. Calculating the binding free energies of charged species based on explicit-solvent simulations employing lattice-sum methods: An accurate correction scheme for electrostatic finite-size effects. J Chem Phys 139, 184103 (2013)

6. Rocklin GJ*, Boyce SE*, Fischer M*, Fish I, Mobley DL, Shoichet BK, Dill KA. Blind prediction of charged ligand binding affinities in a model binding site. J Mol Biol 425, 4569-83 (2013)

5. Rocklin GJ†, Mobley DL, Dill KA. Calculating the Sensitivity and Robustness of Binding Free Energy Calculations to Force Field Parameters. J Chem Theory Comput 9:7, 3072-83 (2013)

4. Rocklin GJ†, Mobley DL, Dill KA. Separated Topologies – a Method for Relative Binding Free Energy Calculations using Orientational Restraints. J Chem Phys 138, 085104 (2013)

3. Boyce SE*, Mobley DL*, Rocklin GJ, Graves AP, Dill KA, Shoichet BK. Predicting ligand binding affinity with alchemical free energy methods in a polar model binding site. J Mol Biol 394, 747- 63 (2009)

2. Teotico DG*, Babaoglu K*, Rocklin GJ, Ferreira RS, Giannetti AM, Shoichet BK. Docking for fragment inhibitors of AmpC beta-lactamase. Proc Natl Acad Sci U S A 106, 7455-60 (2009)

1. DerMardirossian C, Rocklin G, Seo JY, Bokoch GM. Phosphorylation of RhoGDI by Src Regulates RhoGTPase Binding and Cytosol-Membrane Cycling. Mol Biol Cell 17, 4760-8 (2006)