Lab Information

First Name
Last Name
Current Position
Senior Fellow
MolE 420

Personal blurb

Christopher D. Bahl, M.S., Ph.D.

I am a post-doctoral fellow working on establishing a process for the de novo design of small, disulfide stabilized proteins. The goal is to create a method for developing idealized, super-stable protein scaffolds for use in engineering targeted protein binders.

Information about my previous work on the bacterial virulence factor Cif can be found here.



Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR (2015) Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angew Chem Int Ed Engl. 54, 9881-9885.

Bahl CD, Hvorecny KL, Bridges AA, Ballok AE, Bomberger JM, Cady KC, O'Toole GA, Madden DR (2014) Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. J Biol Chem. 289, 7460-7469.

Amacher JF, Cushing PR, Bahl CD, Beck T, Madden DR (2013) Stereochemical Determinants of C-terminal Specificity in PDZ Peptide-Binding Domains: A Novel Contribution of the Carboxylate-Binding Loop. J Biol Chem. 288, 5114-5126.

Ballok AE, Bahl CD, Dolben EL, Lindsay AK, St Laurent JD, Hogan DA, Madden DR, O'Toole GA (2012) Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa. J Bacteriol. 194, 5315-5324.

Bahl CD, Madden DR (2012) Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair. Protein Pept Lett. 19, 186-193.

Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR (2010) Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 192, 1785-1795.

Bahl CD, MacEachran DP, O'Toole GA, Madden DR (2010) Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. Acta Crystallogr. F66, 26-28.


Member for
3 years 11 weeks