Functional inferences from blind ab initio protein structure predictions

TitleFunctional inferences from blind ab initio protein structure predictions
Publication TypeJournal Article
Year of Publication2001
AuthorsBonneau, R., Tsai J., Ruczinski I., & Baker D.
JournalJournal of structural biology
Volume134
Issue2-3
Pagination186-90
Date Published2001 May-Jun
ISSN1047-8477
KeywordsComputational Biology, Models, Chemical, Molecular Structure, Primary Publication, Protein Conformation, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, Proteins
Abstract

Ab initio protein structure prediction methods have improved dramatically in the past several years. Because these methods require only the sequence of the protein of interest, they are potentially applicable to the open reading frames in the many organisms whose sequences have been and will be determined. Ab initio methods cannot currently produce models of high enough resolution for use in rational drug design, but there is an exciting potential for using the methods for functional annotation of protein sequences on a genomic scale. Here we illustrate how functional insights can be obtained from low-resolution predicted structures using examples from blind ab initio structure predictions from the third and fourth critical assessment of structure prediction (CASP3, CASP4) experiments.

Alternate JournalJ. Struct. Biol.
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