Computational design of protein-protein interactions

TitleComputational design of protein-protein interactions
Publication TypeJournal Article
Year of Publication2004
AuthorsKortemme, T., & Baker D.
JournalCurrent opinion in chemical biology
Volume8
Issue1
Pagination91-7
Date Published2004 Feb
ISSN1367-5931
KeywordsBinding Sites, Computer-Aided Design, Humans, Primary Publication, Protein Binding, Protein Structure, Tertiary, Proteins, Substrate Specificity
Abstract

Computational protein design strategies have been developed to reengineer protein-protein interfaces in an automated, generalizable fashion. In the past two years, these methods have been successfully applied to generate chimeric proteins and protein pairs with specificities different from naturally occurring protein-protein interactions. Although there are shortcomings in current approaches, both in the way conformational space is sampled and in the energy functions used to evaluate designed conformations, the successes suggest we are now entering an era in which computational methods can be used to modulate, reengineer and design protein-protein interaction networks in living cells.

Alternate JournalCurr Opin Chem Biol
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