Prediction and design of macromolecular structures and interactions

TitlePrediction and design of macromolecular structures and interactions
Publication TypeJournal Article
Year of Publication2006
AuthorsBaker, D.
JournalPhilosophical transactions of the Royal Society of London
Date Published2006 Mar 29
KeywordsComputer Simulation, Models, Molecular, Primary Publication, Protein Binding, Protein Conformation, Proteins

In this article, I summarize recent work from my group directed towards developing an improved model of intra and intermolecular interactions and applying this improved model to the prediction and design of macromolecular structures and interactions. Prediction and design applications can be of great biological interest in their own right, and also provide very stringent and objective tests which drive the improvement of the model and increases in fundamental understanding. I emphasize the results from the prediction and design tests that suggest progress is being made in high-resolution modelling, and that there is hope for reliably and accurately computing structural biology.

Alternate JournalPhilos. Trans. R. Soc. Lond., B, Biol. Sci.
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