Thanks C&EN!

The lab was honored to be a featured in Chemical & Engineering News’ annual Research of the Year roundup. Under a section titled “Computer-Driven Research Researched New Milestones”, C&EN highlight our determination of “600 families of proteins for which structures had been unknown (Science 2017).” Chemical & Engineering News is a weekly magazine published by …

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New article in Nature: Synthetic nucleocapsids

A report this week describes the first synthetic protein assemblies — dubbed synthetic nucleocapsids — that encapsulate their own genome and evolve in complex environments. The lead authors were Gabe Butterfield and Marc Lajoie. Synthetic nucleocapsids are built to resemble viral capsids and could be used in future to deliver therapeutics to specific cells and …

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New article in Science: Exploring the peptide landscape

IPD researchers report the computational design of a new world of small cyclic peptides, or “macrocycles”. Natural macrocycles such as cyclosporine are among the most potent therapeutics identified to date, having the benefits of small molecule drugs, like aspirin, and large antibody therapies, like rituximab, with fewer drawbacks. There is considerable interest in expanding this …

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New article in Nature: building 20,000 new drug candidates

In another major leap forward, researchers at the IPD have just published a revolutionary method for generating brand new protein drugs. These new drugs – called “mini-protein binders” – combine the specificity of antibodies with the high stability and manufacturability of small molecule drugs. The new de novo designed mini-protein binders were custom built to target either a …

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New article in Science: data-driven protein design

This summer saw a major advance in protein science: data-driven design. For decades, researchers have been trying to decode the rules of protein folding by studying how the complex, highly specialized proteins in nature hold their shapes. It’s a bit like trying to figure out how an airplane works – at its most fundamental level …

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Hiking the Alpine Lakes of the Central Cascades

It’s been a hot summer in Seattle! To escape the heat, the lab headed east to the Alpine Lakes of the Central Cascades. Some hikes were short (just enough to swim in Melakwa Lake) and some were long (tracking until they hit snow). Zibo, a graduate student in the lab, brought a drone along to …

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Computational design of Flu Glue

Today, a multidisciplinary team of researchers at the University of Washington, Fred Hutch, and The Scripps Research Institute published in Nature Biotechnology the computational design of a trimeric influenza-neutralizing protein that binds extremely tightly to the H3 hemagglutinin of 1968 Hong Kong pandemic influenza virus (A/Hong Kong/X31/1968).   It also cross-reacts with human relevant H1, H2 …

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The lab goes to Paradise

After months of grey Seattle skies, the lab leapt at a chance to synthesize some vitamin D in Paradise (an actual place at the base of Mount Rainier). Some snowshoed, some skied, and others showed up in the afternoon for a delicious lab BBQ.  Couldn’t ask for a more beautiful day!

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