New article in Nature: building 20,000 new drug candidates

In another major leap forward, researchers at the IPD have just published a revolutionary method for generating brand new protein drugs. These new drugs – called “mini-protein binders” – combine the specificity of antibodies with the high stability and manufacturability of small molecule drugs. The new de novo designed mini-protein binders were custom built to target either a …

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New article in Science: data-driven protein design

This summer saw a major advance in protein science: data-driven design. For decades, researchers have been trying to decode the rules of protein folding by studying how the complex, highly specialized proteins in nature hold their shapes. It’s a bit like trying to figure out how an airplane works – at its most fundamental level …

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Hiking the Alpine Lakes of the Central Cascades

It’s been a hot summer in Seattle! To escape the heat, the lab headed east to the Alpine Lakes of the Central Cascades. Some hikes were short (just enough to swim in Melakwa Lake) and some were long (tracking until they hit snow). Zibo, a graduate student in the lab, brought a drone along to …

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Computational design of Flu Glue

Today, a multidisciplinary team of researchers at the University of Washington, Fred Hutch, and The Scripps Research Institute published in Nature Biotechnology the computational design of a trimeric influenza-neutralizing protein that binds extremely tightly to the H3 hemagglutinin of 1968 Hong Kong pandemic influenza virus (A/Hong Kong/X31/1968).   It also cross-reacts with human relevant H1, H2 …

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The lab goes to Paradise

After months of grey Seattle skies, the lab leapt at a chance to synthesize some vitamin D in Paradise (an actual place at the base of Mount Rainier). Some snowshoed, some skied, and others showed up in the afternoon for a delicious lab BBQ.  Couldn’t ask for a more beautiful day!

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In case you missed it…

Protein design was a Science magazine runner up breakthrough of the year:  http://www.sciencemag.org/news/2016/12/ai-protein-folding-our-breakthrough-runners (We got beat out by gravitational waves).  

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Protein structure determination using metagenome sequence data

Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families and that metagenome sequence data more than triple the number …

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